SuperSmart's S-Acetyl Glutathione is a dietary supplement that provides reduced glutathione in an S-acetylated form, designed to improve its stability and bioavailability compared to conventional glutathione. This form helps maintain cellular oxidative balance and is suitable as antioxidant support. This innovative form allows glutathione to escape oxidation in the gut, maximizing its bioavailability and effective entry into human body cells. Glutathione is a molecule synthesized naturally in human body cells. It is composed of three amino acids: glutamic acid, cysteine, and glycine. Its production decreases with age, and in certain cases, it is insufficient to properly defend the organism.
Once in the intestine, glutathione molecules are surrounded by intestinal enzymes, gamma-glutamyl transpeptidases, which transform them into relatively useless compounds. However, some molecules escape these attacks: they cross the intestinal barrier even before being oxidized by the enzymes, thus reaching the bloodstream in a fully functional state. Unfortunately, the proportion of these molecules is low, so large quantities of glutathione must be ingested for supplement intake to be truly meaningful. One of the relevant strategies to benefit from glutathione consists of attaching it to an acetyl group to prevent its oxidation by enzymes. Acetylated glutathione then crosses the intestinal barrier, penetrates the cells, and then loses its acetyl group under the effect of cytoplasmic thioesterases. It is one of the most effective solutions for increasing serum glutathione levels, along with the perlingual route. Perlingual glutathione reaches the bloodstream without passing through the intestine and, therefore, without crossing the gamma-glutamyl transpeptidase pathway.
